Salitas FC of Burkina Faso won 2-0 away to Al Masry of Egypt Saturday in the biggest shock so far of 2018/2019 CAF Confederation Cup qualifying.
The Ouagadougou academy outfit are debuting in the second-tier African club competition just one season after being promoted to top-flight football in the west African country.
Salitas even struggled to make the round-of-32 draw, needing the away-goal rule to squeeze past fellow African newcomers Wakriya of Guinea after a 3-3 aggregate deadlock.
But they put nervous preliminary-round performances behind them in Port Said as they rattled Masry, who reached the 2018 Confederation Cup semi-finals.
Egyptian clubs seldom lose at home in CAF competitions, especially against opponents from Burkina Faso, a nation that has never made an impact in the Confederation Cup.
Cedric Badolo ran unchallenged from the centre circle to score on 32 minutes with a shot that was deflected into the net by the Masry goalkeeper.
A spectacular overhead kick from Ismael Karambiri on 72 minutes doubled the lead and left the Egyptians facing a huge recovery mission in Ouagadougou next Saturday.
While Masry are in serious trouble, fellow Egyptians Zamalek went on a goal romp in Cairo to build a 7-0 first-leg lead over hapless ASCOT of Chad.
Chadian resistance lasted just 11 minutes before Mahmoud Kahraba netted and the other scorers included Tunisian Ferjani Sassi and Congolese Kabongo Kasongo, who bagged a brace.
Only Al Ahly of Egypt and TP Mazembe of the Democratic Republic of Congo have won more CAF titles than Zamalek, but the Cairo outfit have not lifted an African trophy since 2003.
CS Sfaxien of Tunisia, winners of the Confederation Cup a record three times, launched their campaign with an ultimately convincing 4-1 home win over Green Buffaloes of Zambia.
Army team Buffaloes came from behind to be level at 1-1 by half-time, but late goals from Hani Amamou and Firas Chaouat left Sfaxien well placed to win the tie.
Etoile Sahel, the other Tunisian challengers, have won the competition twice and a 3-0 home win over Stade Abidjan of the Ivory Coast virtually assures them of overall success.
Karim Aouadhi and Maher Hannachi scored within four minutes during the opening half in Mediterranean resort Sousse and Ahmed Akaichi netted soon after half-time.
A couple of late goals from Colombian Leonardo Castro gave Kaizer Chiefs of South Africa a 3-0 win over ASSM Elgeco Plus of Madagascar in the Indian Ocean port city of Durban.